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Solfrizzi V, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Vendemiale G, et al. DHA and cognitive function in the elderly: a systematic review of the literature. Noel K, Hoffman J, Ellis L, Yurko-Mauro K, Cella C, Sercus B, et al.
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Scientific Opinion on the essential composition of infant and follow-on formulae. Observational studies support a beneficial association between intake/blood levels of DHA/EPA and memory function in older adults.ĭHA, alone or combined with EPA, contributes to improved memory function in older adults with mild memory complaints.ĮFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). Semantic and working memory changes from baseline were significant with DHA but no between group differences were detected. A priori sub-group analyses were conducted to evaluate the effect of age at enrollment, dose level, and memory type tested.Įpisodic memory outcomes of adults with MMC were significantly (P 1 g/day DHA/EPA improved episodic memory (P<.04).
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Random effects meta-analyses were conducted to generate weighted group mean differences, standardized weighted group mean differences (Hedge's g), z-scores, and p-values for heterogeneity comparing DHA/EPA to a placebo.
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Studies of subjects free of neurologic disease at baseline, with or without mild memory complaints (MMC), were included. A secondary objective was to systematically review/summarize the related observational epidemiologic literature.Ī systematic literature search of clinical trials and observational studies that examined the relationship between n-3 LCPUFA on memory outcomes in healthy adults was conducted in Ovid MEDLINE and EMBASE databases. The current meta-analysis was designed to determine the effect of DHA intake, alone or combined with eicosapentaenoic acid (EPA 20:5 n-3), on specific memory domains: episodic, working, and semantic in healthy adults aged 18 years and older. Past research demonstrates a positive association between DHA plasma status/dietary intake and cognitive function. Docosahexaenoic acid (DHA 22:6 n-3) is a long-chain polyunsaturated fatty acid (LCPUFA) and an integral part of neural membrane phospholipids that impacts brain structure and function. Subjective memory complaints are common with aging.